Each site has different needs. Is it a blog for a retail location, or a service company? Is it intended as a professional website or will it serve as an ongoing publication? Think about the services you are offering and what will appear on your site.
A well conceived layout, when combined with proper categorization, will help make it easier for users to navigate and find what they are looking for. Many people want a website with just a few pages and to do so, you will organize your content from a homepage with a menu linking to the remaining pages on your site.